Five months ago Dr. Cristina Gonzalez-Garcia of the Division of Biomedical Engineering won the New Investigator Award from the Engineering and Physical Sciences Research Council thanks to team projet, led by her. The team will develop a new hydrogel, based on the acemannan polysaccharide – main bioactive component from the inner leaves of Aloe Vera – that will act as a bioactive carrier for the efficient and local delivery of GFs for tissue engineering applications (Figure 1 below). This new project, funded through a New Investigator Award from the UKRI EPSRC will support new posts in Dr. Gonzalez-Garcia’s group, within the Centre for the Cellular Microenvironment.
Cancer’s ‘genome doubling’ mystery solved
Researchers at the Crick and UCL have established why some cancer cells exhibit an unusual phenomenon called whole genome doubling, where every chromosome is duplicated. Setting out to understand why this happens, the researchers predicted that the doubling of its genome gives cancer cells a survival advantage by providing them with a genetic ‘spare tyre’. If one copy of the genome gains a lethal mutation, the cell could continue to survive and divide, thanks to its second copy. To test this, the researchers created a computer model to recreate the conditions of cancer evolution and determine whether, in theory, natural selection could favour whole genome doubling.
University of Warwick researchers, working with a network of international collaborators, have discovered 23 previously unexplored compounds containing metals such as silver, manganese, zinc, ruthenium and iridium that have antibacterial and antifungal activity. The study involved work by University of Warwick chemists was led by University of Queensland’s Centre for Superbug Solutions at the Institute for Molecular Bioscience. This research has been published in Chemical Science and is free to read.